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Poster: Longitudinal Changes in the North Star Ambulatory Assessment and Leg Muscle Fat Fraction in DMD

Figure 3 shows four graphs comparing NSAA scores with muscle fat fraction. Top graphs (A,B) are scatter plots showing negative correlations between NSAA scores and fat fraction in soleus (ρ=-0.57) and vastus lateralis (ρ=-0.77) muscles. Bottom graphs (C,D) are bar charts demonstrating how NSAA scores decrease as fat fraction increases across four categories from
Picture of Sean C Forbes, PhD

Sean C Forbes, PhD

Drs. Kelly Rock and Sean Forbes presented research from the ImagingNMD study at the 2024 World Muscle Society Annual Congress, examining the relationship between the North Star Ambulatory Assessment (NSAA) and muscle fat fraction measurements in Duchenne muscular dystrophy (DMD). Their longitudinal study of 90 ambulatory DMD subjects (ages 4-18 years) demonstrated strong correlations between NSAA scores and muscle fat fraction in lower extremity muscles, measured using proton magnetic resonance spectroscopy. The research, conducted across multiple institutions, including the University of Florida and Oregon Health & Science University, suggests that muscle fat fraction measurements can be used to predict functional abilities assessed by the NSAA.

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