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Poster: Relationship of magnetic resonance measures of bone quality with bone mineral density in corticosteroid treated boys with Duchenne muscular dystrophy

Side-by-side comparison of MRI scans of the lower leg. The left image shows the leg of an 8-year-old with DMD, with distinct muscle tissue visible. The right image shows the leg of a 17.5-year-old with DMD, where the muscle tissue appears less defined.
Picture of Remya Kunnath Ravindranunni

Remya Kunnath Ravindranunni

Exploring Bone Health in Becker Muscular Dystrophy

This poster, presented by Remya Kunnath Ravindranunni, PhD Candidate, at the 2025 MDA Clinical & Scientific Conference, showcases findings from a cross-sectional observational study utilizing a 3-Tesla whole body MRI scanner to investigate bone health in boys with Becker Muscular Dystrophy and Duchenne Muscular Dystrophy (DMD). The study measured bone marrow fat fraction (BMFF) from the L4 vertebral body and distal femur using advanced magnetic resonance spectroscopy (MRS) and the Dixon method. High-resolution gradient echo images of the distal femur were analyzed to extract trabecular and cortical bone characteristics, and micro-level finite element analysis (FEA) models were developed to estimate distal femur stiffness. The results demonstrate significant associations between MR measures of bone quality and dual-energy X-ray absorptiometry (DXA) bone mineral density (BMD), highlighting the potential of MRI to leverage existing measures of bone health assessment tools in corticosteroid treated boys with DMD.

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A person wearing black tight and colorful shoes with flower on it, playing the game hopscotch outside, with their left food on the number three and their right foot up in the air.
Null.
I can’t say enough positive things about the entire team. Everyone has consistently gone out of their way to accommodate us & support us. We’ve been participating for so many years that our annual trips feel like we’re reuniting with our good friends.
WY
A person wearing black tight and colorful shoes with flower on it, playing the game hopscotch outside, with their left food on the number three and their right foot up in the air.
Null.
Very important if we can eliminate intrusive biopsies as a necessary requirement for clinical trial evaluation. MRIs are a much preferred “gold standard”.
KT
A person wearing black tight and colorful shoes with flower on it, playing the game hopscotch outside, with their left food on the number three and their right foot up in the air.
Null.
The study has been very exciting. Discovering new tools that can help in the development of more studies and clinical trials for Becker muscular dystrophy. I feel like people are beginning to recognize BMD now.
JV

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