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Poster: MRI gluteal/thigh muscle fat fraction detects NSAD motor task failures in men with Becker muscular dystrophy

Two panel comparison: Left shows MRI scans of gluteal/thigh muscles from two BMD patients - a 61-year-old with less fat infiltration (green=fat, red=muscle) and better NSAD score (51/54), versus a 43-year-old with more fat infiltration and lower NSAD score (25/54). Right panel shows a bar chart of NSAD task performance across participants, with red indicating failure, orange partial completion, and green full completion of tasks.
Picture of Kelly Rock, PT, DPT, PhD

Kelly Rock, PT, DPT, PhD

Dr. Kelly Rock presented new findings from the ImagingNMD study at the 2024 World Muscle Society Annual Congress in Prague, examining the relationship between muscle fat fraction and functional performance in Becker Muscular Dystrophy (BMD). Her research, involving 43 men with BMD, demonstrated that quantitative MRI measurements of gluteal and thigh muscle fat fraction strongly correlate with functional abilities measured by the North Star Assessment for Dysferlinopathies (NSAD) and these fat fraction values could detect the inability to perform relevant NSAD tasks. The study, conducted at the University of Florida and Oregon Health & Science University, suggests that these measurements could serve as valuable biomarkers for future BMD clinical trials.

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Null.
I can’t say enough positive things about the entire team. Everyone has consistently gone out of their way to accommodate us & support us. We’ve been participating for so many years that our annual trips feel like we’re reuniting with our good friends.
WY
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Null.
Very important if we can eliminate intrusive biopsies as a necessary requirement for clinical trial evaluation. MRIs are a much preferred “gold standard”.
KT
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Null.
The study has been very exciting. Discovering new tools that can help in the development of more studies and clinical trials for Becker muscular dystrophy. I feel like people are beginning to recognize BMD now.
JV

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